Synthesis and activity of selective MMP inhibitors with an aryl backbone

A series of novel, MMP-1 sparing arylhydroxamate sulfonamides with activity against MMP-2 and -13 is described.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2000-12, Vol.10 (24), p.2815-2817
Main Authors: E. Barta, Thomas, P. Becker, Daniel, J. Bedell, Louis, A. De Crescenzo, Gary, J. McDonald, Joseph, E. Munie, Grace, Rao, Shashi, Shieh, Huey-Sheng, Stegeman, Roderick, M. Stevens, Anna, I. Villamil, Clara
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Biological and medical sciences
Collagenases - chemistry
Collagenases - metabolism
Crystallography, X-Ray
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - pharmacology
Humans
Hydroxamic Acids - chemical synthesis
Hydroxamic Acids - pharmacology
Inhibitory Concentration 50
Matrix Metalloproteinase 1 - chemistry
Matrix Metalloproteinase 1 - metabolism
Matrix Metalloproteinase 13
Matrix Metalloproteinase 2 - chemistry
Matrix Metalloproteinase 2 - metabolism
Matrix Metalloproteinase Inhibitors
Medical sciences
Miscellaneous
Models, Molecular
Pharmacology. Drug treatments
Structure-Activity Relationship
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Description
Summary:A series of novel, MMP-1 sparing arylhydroxamate sulfonamides with activity against MMP-2 and -13 is described.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00584-9