Design and synthesis of new potent human cytomegalovirus (HCMV) inhibitors based on internally hydrogen-bonded 1,6-naphthyridines

1,6-Naphthyridine-2-carboxylic acid benzylamides are potent anti-HCMV compounds. Replacement of the amide moiety by other groups containing internal hydrogen bonds was undertaken to extend the SAR. Our results indicated that the urca derivatives showed very good activity.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2001-01, Vol.11 (2), p.103-105
Main Authors: CHAN, Laval, STEFANAC, Tomislav, LAVALLEE, Jean-Francois, JIN, Haolun, BEDARD, Jean, MAY, Suzanne, FALARDEAU, Guy
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - chemical synthesis
Antiviral Agents - pharmacology
Biological and medical sciences
Cell Survival - drug effects
Cytomegalovirus - drug effects
Drug Design
Hydrogen Bonding
Inhibitory Concentration 50
Medical sciences
Naphthalenes - chemistry
Naphthyridines - chemical synthesis
Naphthyridines - pharmacology
Pharmacology. Drug treatments
Structure-Activity Relationship
Thioamides - chemical synthesis
Thioamides - chemistry
Thioamides - pharmacology
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Description
Summary:1,6-Naphthyridine-2-carboxylic acid benzylamides are potent anti-HCMV compounds. Replacement of the amide moiety by other groups containing internal hydrogen bonds was undertaken to extend the SAR. Our results indicated that the urca derivatives showed very good activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00607-7