Synthesis and biological activity of sulfoximine-modified myristic acid analogues

Analogues of myristic acid, incorporating a sulfoximine structure in place of the carboxylic acid moiety, were synthesized and found to inhibit some biological processes that are dependent upon a myristoylation event. Sulfoximine analogues, such as 7 , were synthesized and shown to inhibit some biol...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1993-08, Vol.3 (8), p.1717-1722
Main Authors: McDonald, Ian A., Nyce, Philip L., Ku, George S., Bowlin, Terry L.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
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Summary:Analogues of myristic acid, incorporating a sulfoximine structure in place of the carboxylic acid moiety, were synthesized and found to inhibit some biological processes that are dependent upon a myristoylation event. Sulfoximine analogues, such as 7 , were synthesized and shown to inhibit some biological processes that are dependent upon a myristoylation event.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80049-9