Dual-acting thromboxane receptor antagonist/synthase inhibitors: heterocyclic variations

The ability of 1,3-dioxanes bearing a variety of aromatic heterocycles at C4 to inhibit thromboxane synthase has been examined. Potent dual-acting thromboxane receptor antagonist/thromboxane synthase inhibitors have been discovered. The ability of 1,3-dioxanes bearing a variety of aromatic heterocyc...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1992-10, Vol.2 (10), p.1181-1186
Main Authors: Faull, A.W., Gaskin, H., Hadfield, P.S., Jessup, R., Russell, K., Watkins, W.J., Wayne, M.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The ability of 1,3-dioxanes bearing a variety of aromatic heterocycles at C4 to inhibit thromboxane synthase has been examined. Potent dual-acting thromboxane receptor antagonist/thromboxane synthase inhibitors have been discovered. The ability of 1,3-dioxanes bearing a variety of aromatic heterocycles at C4 to inhibit thromboxane synthase has been examined. Potent dual-acting thromboxane receptor antagonist/thromboxane synthase inhibitors have been discovered.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80210-3