The first total synthesis of the antithrombin III binding site of porcine mucosa heparin

The synthesis of a pentasaccharide containing a N-acetyl-glucosamine unit and corresponding to the major natural sequence required in heparin for binding to antithrombin III is reported for the first time. This compound elicits anti-factor Xa activity and high affinity for antithrombin III. This pen...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1991, Vol.1 (2), p.99-102
Main Authors: Duchaussoy, P., Lei, P.S., Petitou, M., Sinaÿ, P., Lormeau, J.C., Choay, J.
Format: Article
Language:English
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Summary:The synthesis of a pentasaccharide containing a N-acetyl-glucosamine unit and corresponding to the major natural sequence required in heparin for binding to antithrombin III is reported for the first time. This compound elicits anti-factor Xa activity and high affinity for antithrombin III. This pentasaccharide represents the binding site of pig mucosa heparin to antithrombin III.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80239-5