Synthesis and antitumor evaluation of water soluble taxol phosphates

Synthesis and in vivo antitmor evaluation of water soluble 2′- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro . Water soluble tax...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1993-06, Vol.3 (6), p.1357-1360
Main Authors: Vyas, Dolatrai M., Wong, Henry, Crosswell, Alfred R., Casazza, Anna Maria, Knipe, Jay O., Mamber, Stephen W., Doyle, Terrence W.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Synthesis and in vivo antitmor evaluation of water soluble 2′- and 7-taxol phosphates is reported. These derivatives were found to be poor prodrugs of taxol based on their marginal in vivo antitumor activity against ip,ip M109 murine tumor model and taxol release studies in vitro . Water soluble taxol phosphates 3 and 4 are not suitable prodrugs of taxol.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80348-0