Synthesis and cyclooxygenase and 5-lipoxygenase inhibitory activity of some thiazolidene-4-one analogs of meclofenamic acid

Replacement of the carboxylic acid functionality of meclofenamic acid with select heterocycles converted this cyclooxygenase (CO) inhibitor into dual inhibitors of CO and 5-lipoxygenase (5-LO). Replacing the carboxylic acid functionality of meclofenamic acid with select heterocycles converted this c...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1992-07, Vol.2 (7), p.705-708
Main Authors: Boschelli, Diane H., Connor, David T., Kuipers, Paul J., Wright, Clifford D.
Format: Article
Language:English
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Summary:Replacement of the carboxylic acid functionality of meclofenamic acid with select heterocycles converted this cyclooxygenase (CO) inhibitor into dual inhibitors of CO and 5-lipoxygenase (5-LO). Replacing the carboxylic acid functionality of meclofenamic acid with select heterocycles converted this cyclooxygenase (CO) inhibitor into dual inhibitors of CO and 5-lipoxygenase (5-LO).
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80396-0