The synthesis and identification of 4,6-diaminoquinoline derivatives as potent immunostimulants

The synthesis of a number of 4,6-diaminoquinoline derivatives is described as well as their evaluation in a mouse protection model designed to identify immunostimulant activity. These compounds represent a novel series of potent immunostimulants. The synthesis of a number of 4,6-diaminoquinoline der...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1992-12, Vol.2 (12), p.1589-1594
Main Authors: Moyer, Mikel P., Weber, Frederick H., Gross, Jonathan L., Isaac, Joseph W., Fort, Ralph Saint
Format: Article
Language:English
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Summary:The synthesis of a number of 4,6-diaminoquinoline derivatives is described as well as their evaluation in a mouse protection model designed to identify immunostimulant activity. These compounds represent a novel series of potent immunostimulants. The synthesis of a number of 4,6-diaminoquinoline derivatives is described as well as their evaluation in a mouse protection model designed to identify immunostimulant activity. These compounds represent a novel series of potent immunostimulants.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80436-9