Structurally novel antiarrhythmic / antioxidant quinazolines

We report a structurally novel series of quinazolines with in vivo antiarrhythmic and/or in vitro iron-dependent lipid peroxidation inhibitory activity. Two analogues, 7 and 12, were evaluated in a canine model of regional myocardial ischemia and reperfusion. In vitro and vivo evaluation of quinazol...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1992-09, Vol.2 (9), p.1121-1126
Main Authors: Yu, Melvin J., McCowan, Jefferson R., Towner, Richard D., Ho, Peter P.K., Phebus, Lee A., Ruterbories, Kenneth J., Lindstrom, Terry D., Boyd, Robert, Jackson, William T., Ertel, Phillip J., Steinberg, Mitchell I., Murphy, Anthony, Breau, Alan, Donald Pollock, G., Hahn, Richard A.
Format: Article
Language:English
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Summary:We report a structurally novel series of quinazolines with in vivo antiarrhythmic and/or in vitro iron-dependent lipid peroxidation inhibitory activity. Two analogues, 7 and 12, were evaluated in a canine model of regional myocardial ischemia and reperfusion. In vitro and vivo evaluation of quinazolines 1 – 12 is reported:
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)80631-9