Schotten-Baumann acylation of N-debenzoyltaxol; an efficient route to N-acyl taxol analogues and their biological evaluation

An efficient route to N-acyl taxol analogues is described utilizing N-debenzoyltaxol ( 11). Acylation of 11 with various acid chlorides under Schotten-Baumann conditions led to a facile one step synthesis of several N-acyl taxol analogues from a common intermediate. Graphic

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1994-01, Vol.4 (2), p.335-338
Main Authors: Georg, Gunda I., Boge, Thomas C., Cheruvallath, Zacharia S., Harriman, Geraldine C.B., Hepperle, Michael, Park, Haeil, Himes, Richard H.
Format: Article
Language:English
Subjects:
Alicyclic compounds, terpenoids, prostaglandins, steroids
Chemistry
Exact sciences and technology
Organic chemistry
Preparations and properties
Terpenoids
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Summary:An efficient route to N-acyl taxol analogues is described utilizing N-debenzoyltaxol ( 11). Acylation of 11 with various acid chlorides under Schotten-Baumann conditions led to a facile one step synthesis of several N-acyl taxol analogues from a common intermediate. Graphic
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80139-6