Synthesis and antiviral activity of 3-substituted imidazo[1,2- a]pyridines

A series of 3-substituted imidazo[1,2- a]pyridines wa synthesized as potential antiviral agents. Compound 10b and, to a lesser extent, 10c showed activity against both TK + and TK − strains of varicella-zoster virus. A series of 3-substituted imidazo[1,2- a]pyridines was synthesized. Compound 10b sh...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1994-08, Vol.4 (16), p.1937-1940
Main Authors: Elhakmaoui, Ahmed, Gueiffier, Alain, Milhavet, Jean-Claude, Blache, Yves, Chapat, Jean-Pierre, Chavignon, Olivier, Teulade, Jean-Claude, Snoeck, Robert, Andrei, Graciela, De Clercq, Erik
Format: Article
Language:English
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Summary:A series of 3-substituted imidazo[1,2- a]pyridines wa synthesized as potential antiviral agents. Compound 10b and, to a lesser extent, 10c showed activity against both TK + and TK − strains of varicella-zoster virus. A series of 3-substituted imidazo[1,2- a]pyridines was synthesized. Compound 10b showed activity against varicella-zoster virus.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80538-2