Synthesis and study of a non macrocyclic FK506 derivative

The affinity of a non macrocyclic analogue of FK506 for the immunophilin FKBP12 was determined The affinity of this analogue/FKBP12 complex for calcineurin was studied. The affinity of a non macrocycli analogue of FK506 for the immunophilin FKBP12 was determined. The affinity of this analogue/FKBP12...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1994-07, Vol.4 (13), p.1581-1584
Main Authors: Teague, Simon J., Cooper, Martin E., Donald, David K., Furber, Mark
Format: Article
Language:English
Subjects:
Biological and medical sciences
Immunomodulators
Medical sciences
Pharmacology. Drug treatments
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Summary:The affinity of a non macrocyclic analogue of FK506 for the immunophilin FKBP12 was determined The affinity of this analogue/FKBP12 complex for calcineurin was studied. The affinity of a non macrocycli analogue of FK506 for the immunophilin FKBP12 was determined. The affinity of this analogue/FKBP12 complex for calcineurin was studied.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80570-9