An approach towards thiol mediated labelling in the minor groove of oligonucleotides

The preparation of an appropriately protected 2′- O-(2-thioethyl)uridine phosphoramidite is reported along with its incorporation into an oligonucleotide and post-synthetic labelling. The preparation of a modified uridine phosphoramidite 1 and its incorporation into an oligonucleotide are described....

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1994-04, Vol.4 (8), p.995-1000
Main Authors: Douglas, Mark E., Beijer, Barbro, Sproat, Brian S.
Format: Article
Language:English
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Summary:The preparation of an appropriately protected 2′- O-(2-thioethyl)uridine phosphoramidite is reported along with its incorporation into an oligonucleotide and post-synthetic labelling. The preparation of a modified uridine phosphoramidite 1 and its incorporation into an oligonucleotide are described.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80669-7