Chiral carbocylic nucleosides: The synthesis and antiviral activity of 4′-hydroxy and 4′-fluorocarbocyclic - 2′- deoxyguanosines

The chiral carbocyclic nucleosides 2 and 3 were prepared from aristeromycin. The 4′α-hydroxy compound 2 displays good antiviral activity against HSV-1 and HSV-2 with low toxicity. The chiral carbocyclic nucleosides 2 and 3 where prepared from aristeromycin. The 4′α-hydroxy compound 2 displays good a...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1993, Vol.3 (12), p.2577-2580
Main Authors: Borthwick, Alan D., Biggadike, Keith, Paternoster, Ian L., Coates, Jonathan A.V., Knight, David J.
Format: Article
Language:English
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Summary:The chiral carbocyclic nucleosides 2 and 3 were prepared from aristeromycin. The 4′α-hydroxy compound 2 displays good antiviral activity against HSV-1 and HSV-2 with low toxicity. The chiral carbocyclic nucleosides 2 and 3 where prepared from aristeromycin. The 4′α-hydroxy compound 2 displays good antiviral activity against HSV-1 and HSV-2 with low toxicity.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80719-8