pH dependence of the baker's yeast conversion of 4-benzoyloxy-crotonaldehyde into the 1-benzoate of (2R) 1,2,4-butanetriol

In the baker's yeast mediated conversion of 4-benzoyloxycrotonaldeyde (5) ito the 1-benzoate of (2R) 1,2,4-butanetriol (7) there is a market dependence of the ee values from the pH, nearly racemic materials being obtained over pH 4.6. In the baker's yeast mediated conversion of 4-benzoylox...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1993-12, Vol.3 (12), p.2785-2788
Main Authors: Fuganti, Claudio, Lanati, Simonetta, Servi, Stefano, Tagliani, Auro
Format: Article
Language:English
Subjects:
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
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Summary:In the baker's yeast mediated conversion of 4-benzoyloxycrotonaldeyde (5) ito the 1-benzoate of (2R) 1,2,4-butanetriol (7) there is a market dependence of the ee values from the pH, nearly racemic materials being obtained over pH 4.6. In the baker's yeast mediated conversion of 4-benzoyloxy crotonaldehyde (5) into the 1-benzoate of (2R) 1,2,4-butanetriol (7) there is a marked dependence of the ee values from the pH, nearly racemic materials being obtained over pH 4.6.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80764-2