Synthesis and release of doxorubicin from a cephalosporin based prodrug by a β-lactamase-immunoconjugate

A cephalosporin based prodrug of doxorubicin has been synthesized which effciently releases doxorubicin in the presence of an immunoconjugate consisting of a β-lactamase-MAb. A cephalosporin based prodrug ( 4) of doxorubicin has been sythesized which efficiently releases doxorubicin in the presence...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1993-02, Vol.3 (2), p.323-328
Main Authors: Hudyma, Thomas W., Bush, Karen, Colson, Kimberly L., Firestone, Raymond A., King, H.Dalton
Format: Article
Language:English
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Summary:A cephalosporin based prodrug of doxorubicin has been synthesized which effciently releases doxorubicin in the presence of an immunoconjugate consisting of a β-lactamase-MAb. A cephalosporin based prodrug ( 4) of doxorubicin has been sythesized which efficiently releases doxorubicin in the presence of an immunoconjugate consisting of a β-lactamase-MAb.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80902-1