Activity of new penems against defined MRSA strains

The activity of penems against methicillin-resistant Staphylococcus aureus (MRSA) was determined on strains representative of the four expression classes of resistance. Two families of compounds, characterized by a C2-(hetero)aromatic moiety connected by an ether (CH 2O) or ester (CH 2OCO) link, dis...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1993-11, Vol.3 (11), p.2165-2170
Main Authors: Jabès, Daniela, Rossi, Rosaria, Bruna, Costantino Della, Perrone, Ettore, Alpegiani, Marco, Andreini, Bianca P., Visentin, Giuseppina, Zarini, Franco, Franceschi, Giovanni
Format: Article
Language:English
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Summary:The activity of penems against methicillin-resistant Staphylococcus aureus (MRSA) was determined on strains representative of the four expression classes of resistance. Two families of compounds, characterized by a C2-(hetero)aromatic moiety connected by an ether (CH 2O) or ester (CH 2OCO) link, displayed superior activity in vitro. The activity of penems against methicillin-resistant Staphylococcus aureus (MRSA) was determined on strains representative of the four expression classes of resistance. Two families of penems (I and II), characterized by (hetero)aromatic moieties connected at the C2 atom of the ring by an ether (CH 2O) or ester (CH 2OCO) bridge, displayed in vitro activity superior to that of reference compounds of the β-lactam class (imipenem, meropenem).
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)80919-7