Justicidin E: A new leukotriene biosynthesis inhibitor

Justicidin E, an arylnaphthalene lignan, has been identified as a potent inhibitor of leukotriene biosynthesis by human leukocytes (IC 50 = 70 nM) and a non-redox inhibitor of 5-lipoxygenase activity. Justicidin E, an arylnaphthalene lignan, has been identified as a potent inhibitor of leukotriene b...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1993-10, Vol.3 (10), p.2063-2066
Main Authors: Thérien, M., Fitzsimmons, B.J., Scheigets, J., Macdonald, D., Choo, L.Y., Guay, J., Falgueyret, J.P., Riendeau, D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
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Summary:Justicidin E, an arylnaphthalene lignan, has been identified as a potent inhibitor of leukotriene biosynthesis by human leukocytes (IC 50 = 70 nM) and a non-redox inhibitor of 5-lipoxygenase activity. Justicidin E, an arylnaphthalene lignan, has been identified as a potent inhibitor of leukotriene biosynthesis by human leukocytes (IC 50 = 70 nM) and a non-redox inhibitor of 5-lipoxygenase activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)81016-7