1H-1,2,4-triazole angiotensin II receptor antagonists: N-phenylpyridinylmethyl and N-pyridinylphenylmethyl analogs of SC-50560

Substituting nitrogen for carbon in the pyridinylphenylmethyl analogs of SC-50560 proved to be detrimental, however, the two phenylpyridinylmethyl analogs of SC-50560 retained their potencies. Of these two analogs, SC-52458 was found to have superior in vivo properties. Substituting nitrogen for car...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1994-01, Vol.4 (1), p.99-104
Main Authors: Reitz, David B., Penick, Mark A., Reinhard, Emily J., Cheng, Brian K., Olins, Gillian M., Corpus, Valerie M., Palomo, Maria A., McGraw, Dean E., McMahon, Ellen G.
Format: Article
Language:English
Subjects:
Antihypertensive agents
Biological and medical sciences
Cardiovascular system
Medical sciences
Pharmacology. Drug treatments
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Summary:Substituting nitrogen for carbon in the pyridinylphenylmethyl analogs of SC-50560 proved to be detrimental, however, the two phenylpyridinylmethyl analogs of SC-50560 retained their potencies. Of these two analogs, SC-52458 was found to have superior in vivo properties. Substituting nitrogen for carbon in the four pyridinylphenylmethyl analogs of SC-50560 proved to be detrimental, however, the two phenylpyridinylmethyl analogs of SC-50560 retained their potencies. Of these two analogs, SC-52458 was found to have superior in vivo properties.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(01)81129-X