Synthesis, anticholinesterase activity and structure–Activity relationships of m-Aminobenzoic acid derivatives

The synthesis, acetylcholinesterase inhibitory capacity and structure–activity relationships of simple-structured m-Aminobenzoic acid derivatives are reported. Compound 1b was found to be more potent than galanthamine and tacrine in inhibiting acetylcholinesterase. The synthesis, acetylcholinesteras...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2003-05, Vol.13 (10), p.1825-1827
Main Authors: Trujillo-Ferrara, José, Montoya Cano, Leticia, Espinoza-Fonseca, Michel
Format: Article
Language:English
Subjects:
4-Aminobenzoic Acid - chemical synthesis
4-Aminobenzoic Acid - pharmacology
Animals
Biological and medical sciences
Cholinesterase Inhibitors - chemical synthesis
Cholinesterase Inhibitors - pharmacology
Humans
Hydrophobic and Hydrophilic Interactions
Inhibitory Concentration 50
Medical sciences
Models, Molecular
Molecular Conformation
Neuropharmacology
Pharmacology. Drug treatments
Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)
Psychology. Psychoanalysis. Psychiatry
Psychopharmacology
Structure-Activity Relationship
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Summary:The synthesis, acetylcholinesterase inhibitory capacity and structure–activity relationships of simple-structured m-Aminobenzoic acid derivatives are reported. Compound 1b was found to be more potent than galanthamine and tacrine in inhibiting acetylcholinesterase. The synthesis, acetylcholinesterase inhibitory capacity and SAR of m-Aminobenzoic acid derivatives are reported.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(03)00198-7