Synthesis and structure-activity relationships of 9-substituted acridines as endothelin-A receptor antagonists

Screening of a compound library against endothelin receptors (ET A and ET B) revealed PD 102566 (compound 1) as an ET A selective antagonist. Synthesis and structure-activity relationships (SAR) of a series of analogs are described. Screening of a compound library against endothelin receptors (ET A...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1996-12, Vol.6 (24), p.2999-3002
Main Authors: Cheng, X.-M., Lee, C., Klutchko, S., Winters, T., Reynolds, E.E., Welch, K.M., Flynn, M.A., Doherty, A.M.
Format: Article
Language:English
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Summary:Screening of a compound library against endothelin receptors (ET A and ET B) revealed PD 102566 (compound 1) as an ET A selective antagonist. Synthesis and structure-activity relationships (SAR) of a series of analogs are described. Screening of a compound library against endothelin receptors (ET A and ET B) revealed PD 102566 (compound 1) as an ET A selective antagonist. Synthesis and structure-activity relationships (SAR) of a series of analogs are described.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(96)00551-3