Effects of CpG methylation to double stranded DNA breaks by Cu(II)-podophyllotoxin derivative complexes

Site-specific double stranded DNA breaks by ·OH radicals generated from podophyllotoxin related compounds in the presence of Cu(II) ion were investigated and the neighboring effects of 5-methylcytosine on double stranded DNA cleavage, especially on methylated CpG sites, were evaluated. The neighbori...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1997-02, Vol.7 (4), p.489-494
Main Authors: Tawa, Riichi, Takami, Masashi, Imakura, Yasuhiro, Lee, Kuo-Hsiung, Sakurai, Hiromu
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
General aspects
Medical sciences
Pharmacology. Drug treatments
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Summary:Site-specific double stranded DNA breaks by ·OH radicals generated from podophyllotoxin related compounds in the presence of Cu(II) ion were investigated and the neighboring effects of 5-methylcytosine on double stranded DNA cleavage, especially on methylated CpG sites, were evaluated. The neighboring effects of 5-methylcytosine on double stranded DNA breaks by OH radicals generated from podophyllotoxin related compounds in the presence of Cu(II) ion were investigated.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)00015-2