Anthraquinones related to rhein inhibit glucose uptake into chondrocytes. A mechanism for anti-osteoarthritis drugs?

Rhein has been shown to inhibit the uptake of glucose into Ehrlich Ascites tumor cells. In this paper we show that a wide range of antrhaquinones related to rhein can also inhibit glucose uptake into chondrocytes, many significantly more than the parent molecule. Rhein inhibits the uptake of glucose...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1997-04, Vol.7 (7), p.817-822
Main Authors: Carney, Stephen L., Broadmore, Richard J., Tomlinson, Rosemarie, Kingston, Ann, Gallagher, Peter T., Owton, W.Martin, Miles, Martin V., Brunavs, Michael, Smith, Colin W., Hicks, Terry A., Dobson, David R., Steggles, David J., Ambler, Samantha J., Halliday, Kelly A.
Format: Article
Language:English
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Summary:Rhein has been shown to inhibit the uptake of glucose into Ehrlich Ascites tumor cells. In this paper we show that a wide range of antrhaquinones related to rhein can also inhibit glucose uptake into chondrocytes, many significantly more than the parent molecule. Rhein inhibits the uptake of glucose into Ehrlich Ascites tumor cells. In this paper we show that its analogues also inhibit glucose uptake into chondrocytes, many significantly more than the parent molecule.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)00102-9