Search for surrogates: A study of endothelin receptor antagonist structure activity relationships

The aryloxymethylene group was used as a replacement for an ester or amide bond present in a series of ET A selective endothelin antagonists. The effect of such replacement on the binding affinity is described. The aryloxymethylene group was used as a replacement for an ester or amide bond present i...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1997-04, Vol.7 (7), p.933-938
Main Authors: Raju, B., Okun, Ilya, Stavros, Fiona, Chan, Ming Fai
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiovascular system
Medical sciences
Miscellaneous
Pharmacology. Drug treatments
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Summary:The aryloxymethylene group was used as a replacement for an ester or amide bond present in a series of ET A selective endothelin antagonists. The effect of such replacement on the binding affinity is described. The aryloxymethylene group was used as a replacement for an ester or amide bond present in a series of ET A selective endothelin antagonists. The effect of such replacement on the binding affinity is described.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)00132-7