SPORANDOL: A NOVEL ANTIPARASITIC BINAPHTHALENE FROM CHRYSOSPORIUM MERIDARIUM

Sporandol (7,7′-diacetyl-1, 1′,8,8′-tetrahydroxy-3, 3′-dimethoxy-6, 6′-dimethyl-2, 2′-binaphthalene, 1) a novel endo and ecto parasiticide has been isolated from Chrysosporium meridarium. This compound appears to have much less mammalian toxicity than other members of the binaphthalene class. Axial...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1997-05, Vol.7 (10), p.1279-1282
Main Authors: Tsipouras, Athanasios, Goetz, Michael A., Hensens, Otto D., Liesch, Jerrold M., Ostlind, Dan A., Williamson, Joanne M., Dombrowski, Anne W., Ball, Richard G., Singh, Sheo B.
Format: Article
Language:English
Subjects:
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Applied microbiology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
General aspects
Microbiology
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Summary:Sporandol (7,7′-diacetyl-1, 1′,8,8′-tetrahydroxy-3, 3′-dimethoxy-6, 6′-dimethyl-2, 2′-binaphthalene, 1) a novel endo and ecto parasiticide has been isolated from Chrysosporium meridarium. This compound appears to have much less mammalian toxicity than other members of the binaphthalene class. Axial stereochemistry of sporandol was determined as S by CD measurements. © 1997 Elsevier Science Ltd.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)00226-6