Synthesis and antirheumatic activity of novel tetrahydroquinoline-8-carboxylic acid derivatives

A study of the modification of N-alkylanthranilic acids to develop novel DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone destruction. A study of the modification of N-alkyl...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1997-06, Vol.7 (12), p.1515-1518
Main Authors: Kohno, Yasushi, Awano, Katsuya, Miyashita, Mitsutomo, Fujimori, Shizuyoshi, Kuriyama, Kazuhiko, Sakoe, Yasuhiko, Kudoh, Shinji, Saito, Koji, Kojima, Eisuke
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Medical sciences
Pharmacology. Drug treatments
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Summary:A study of the modification of N-alkylanthranilic acids to develop novel DMARDs is detailed. 1,2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone destruction. A study of the modification of N-alkylanthranilic acids to develop novel DMARDs is detailed. 1.2,3,4-Tetrahydroquinoline-8-carboxylic acid derivatives were found to exhibit a therapeutic effect on adjuvant arthritis and a suppressive effect on bone destruction.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)00261-8