An efficient synthesis of pyrrolo[2,1- c][1,4]benzodiazepine antibiotics via reductive cyclization

A new and convenient one-pot synthesis of pyrrolo[2,1- c][1,4]benzodiazepine (PBD) ring system has been achieved by a reductive cyclization employing N,N-dimethylhydrazine and FeCl 3.6H 2O in good yields. Graphic

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1997-07, Vol.7 (14), p.1825-1828
Main Authors: Kamal, Ahmed, Reddy, B.S.Nararyan, Reddy, B.S.Praveen
Format: Article
Language:English
Subjects:
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Organic chemistry
Preparations and properties
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Description
Summary:A new and convenient one-pot synthesis of pyrrolo[2,1- c][1,4]benzodiazepine (PBD) ring system has been achieved by a reductive cyclization employing N,N-dimethylhydrazine and FeCl 3.6H 2O in good yields. Graphic
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)00314-4