Synthesis of new 3-thiosubstituted carbacephem antibiotics and their activity against penicillin resistant Streptococcus pneumoniae

The synthesis of a series of 3-thiosubstituted carbacephem derivatives is described. The compounds were assayed against penicillin susceptible, intermediate and resistant strains of Streptococcus pneumoniae. Several analogs displayed potent in vitro activity against these organisms. The synthesis of...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1997-09, Vol.7 (17), p.2261-2264
Main Authors: Blaszczak, Larry C., Eid, Clark N., Flokowitsch, Jane, Gregory, G.Stuart, Hitchcock, Stephen A., Huffman, George W., Mayhugh, Daniel R., Nesler, Michael J., Preston, David A., Zia-Ebrahimi, Mohammad
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
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Summary:The synthesis of a series of 3-thiosubstituted carbacephem derivatives is described. The compounds were assayed against penicillin susceptible, intermediate and resistant strains of Streptococcus pneumoniae. Several analogs displayed potent in vitro activity against these organisms. The synthesis of a series of 3-thiosubstituted carbacephem derivatives is described. Several analogs displayed potent in vitro activity against penicillin susceptible, intermediate and resistant strains of Streptococcus pneumoniae.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)00412-5