Synthesis of 7-chloro-4-substituted aminoquinolines and their in vitro ability to produce methemoglobin in canine hemolysate

Synthesis of aminoquinoline derivatives (2–15) and their in vitro effects on methemoglobin formation and methemoglobin reductase activity are delineated. Some of the screened compounds have shown considerable methemoglobin toxicity. Synthesis of aminoquinoline derivatives ( 2–15) and their in vitro...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1997-11, Vol.7 (21), p.2741-2746
Main Authors: Srivastava, Sandhya, Tewari, Swati, Srivastava, Sanjay K., Chauhan, P.M.S., Bhaduri, A.P., Puri, S.K., Pandey, V.C.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Medical sciences
Pharmacology. Drug treatments
Toxicity: blood
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Summary:Synthesis of aminoquinoline derivatives (2–15) and their in vitro effects on methemoglobin formation and methemoglobin reductase activity are delineated. Some of the screened compounds have shown considerable methemoglobin toxicity. Synthesis of aminoquinoline derivatives ( 2–15) and their in vitro effects on methemoglobin formation and methemoglobin reductase activity are delineated. Some of the screened compounds have shown considerable methemoglobin toxicity.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)10074-9