Synthesis of conformationally constrained potential inhibitors of mammalian metalloproteinases

The synthesis of carbocyclic molecules containing functional groups capable of interacting with appropriate binding sites in certain metalloproteinases is described. Preliminary biological evaluation reveals modest inhibitory activity for a thioether analog in the trisubstituted cyclopropane series....

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1997-12, Vol.7 (24), p.3119-3124
Main Authors: Hanessian, Stephen, Griffin, Andrew, Devasthale, Pratik V
Format: Article
Language:English
Subjects:
Antineoplastic agents
Biological and medical sciences
General aspects
Medical sciences
Pharmacology. Drug treatments
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Summary:The synthesis of carbocyclic molecules containing functional groups capable of interacting with appropriate binding sites in certain metalloproteinases is described. Preliminary biological evaluation reveals modest inhibitory activity for a thioether analog in the trisubstituted cyclopropane series. Graphic
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)10171-8