Oligoribonucleotides containing 8-oxo-7,8-dihydro-guanosine and 8-oxo-7,8-dihydro-2′-O-methylguanosine: Synthesis and base pairing properties

7,8-Dihydroguanosine(8-oxoG) and 7,8-dihydro-2′-O-methylguanosine(8-oxoG-Me) were chemically synthesized. Oligoribonucleotides which contain 8-oxoG or 8-oxoG-Me were synthesized. Incorporation of nucleotides opposite 8-oxoG and 8-oxoG-Me with dNTP by MMLV reverse transcriptase during cDNA synthesis...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1998-04, Vol.8 (8), p.939-944
Main Authors: Kim, Sang Kook, Yokoyama, Shigeyuki, Takaku, Hiroshi, Moon, Byung Jo
Format: Article
Language:English
Subjects:
Carbohydrates. Nucleosides and nucleotides
Chemistry
Exact sciences and technology
Nucleosides, nucleotides and oligonucleotides
Organic chemistry
Preparations and properties
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Summary:7,8-Dihydroguanosine(8-oxoG) and 7,8-dihydro-2′-O-methylguanosine(8-oxoG-Me) were chemically synthesized. Oligoribonucleotides which contain 8-oxoG or 8-oxoG-Me were synthesized. Incorporation of nucleotides opposite 8-oxoG and 8-oxoG-Me with dNTP by MMLV reverse transcriptase during cDNA synthesis was characterized. Oligoribonucleotides containing 8-oxoG or 8-oxoG-Me were synthesized by the phosphoramidite method. Incorporation of nucleotides opposite 8-oxoG and 8-oxoG-Me with dNTPs by MMLV reverse transcriptase during cDNA synthesis was characterized.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00150-4