Inhibitors of the bacterial cell wall biosynthesis enzyme Mur D

A series of transition-state analog inhibitors of the d-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme. A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of ba...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1998-07, Vol.8 (13), p.1643-1648
Main Authors: Gegnas, Laura D., Waddell, Sherman T., Chabin, Renee M., Reddy, Sreelatha, Wong, Kenny K.
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
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Summary:A series of transition-state analog inhibitors of the d-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme. A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00285-6