Novel cytokine release inhibitors. Part II: Steroids

Steroidal derivatives as IL-1β release inhibitors are discussed. Steroidal derivatives as IL-1β release inhibitors are discussed.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1998-10, Vol.8 (20), p.2825-2828
Main Authors: Wei He, Huang, Fu-Chih, Morytko, Michael, Jariwala, Navin, Yu, Kin-Tak
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Cells, Cultured
Humans
Inhibitory Concentration 50
Interleukin-1 - antagonists & inhibitors
Interleukin-1 - metabolism
Medical sciences
Monocytes - drug effects
Monocytes - metabolism
Pharmacology. Drug treatments
Steroids - chemistry
Steroids - pharmacology
Structure-Activity Relationship
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Description
Summary:Steroidal derivatives as IL-1β release inhibitors are discussed. Steroidal derivatives as IL-1β release inhibitors are discussed.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00521-6