Synthesis of 25-aminosterols, new antifungal agents

25-aminolanostenol 1 and 25-aminocholesterol 2 were hemisynthesized from natural sterols and tested in vitro against Candida albicans. The biological activity of compound 1 was rather weak, whereas 2 exhibited in vitro antifungal activity with MIC value of 4 μM. Cholesterol and lanosterol derivative...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1999-06, Vol.9 (11), p.1599-1600
Main Authors: Beuchet, P., Dherbomez, M., Elkiel, L., Charles, G., Letourneux, Y.
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - chemical synthesis
Biological and medical sciences
Candida albicans - drug effects
Cholesterol - analogs & derivatives
Cholesterol - chemical synthesis
Inhibitory Concentration 50
Lanosterol - analogs & derivatives
Lanosterol - chemical synthesis
Medical sciences
Models, Chemical
Pharmacology. Drug treatments
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:25-aminolanostenol 1 and 25-aminocholesterol 2 were hemisynthesized from natural sterols and tested in vitro against Candida albicans. The biological activity of compound 1 was rather weak, whereas 2 exhibited in vitro antifungal activity with MIC value of 4 μM. Cholesterol and lanosterol derivatives with nitrogen functionalities at C-25 have been synthesized as new antifungal agents. 2 exhibited in vitro antifungal activity on Candida albicans at 4 μM (MIC).
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(99)00233-4