Synthesis, electrochemistry, and molluscicidal activity of nitroaromatic compounds: effects of substituents and the role of redox potential

Molluscicidal bioassays and electrochemical studies (measurement of first wave reduction potential, Epc1) were performed on several synthetic nitroaromatics, in relation to possible correlation between biological activity, redox potential and structural effects. Five of them presented a significant...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2001-03, Vol.9 (3), p.659-664
Main Authors: de Abreu, Fabiane C., de Paula, Francine S., dos Santos, Aldenir F., Sant'Ana, Antônio Euzébio G., de Almeida, Mauro V., Cesar, Eloi T., Trindade, Márcio N., Goulart, Marı́lia O.F.
Format: Article
Language:English
Subjects:
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiparasitic agents
Antiparasitic Agents - chemical synthesis
Antiparasitic Agents - chemistry
Antiparasitic Agents - pharmacology
Biological and medical sciences
Chemical control
Control
Electrochemistry
Fundamental and applied biological sciences. Psychology
Inhibitory Concentration 50
Medical sciences
Mollusca - drug effects
Nitro Compounds - chemical synthesis
Nitro Compounds - pharmacology
Nitrobenzenes - chemical synthesis
Nitrobenzenes - chemistry
Nitrobenzenes - pharmacology
Oxidation-Reduction
Pharmacology. Drug treatments
Phytopathology. Animal pests. Plant and forest protection
Protozoa. Invertebrates
Schistosomiasis mansoni - drug therapy
Snails - drug effects
Structure-Activity Relationship
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Summary:Molluscicidal bioassays and electrochemical studies (measurement of first wave reduction potential, Epc1) were performed on several synthetic nitroaromatics, in relation to possible correlation between biological activity, redox potential and structural effects. Five of them presented a significant molluscicidal activity on Biomphalaria glabrata (LD 50
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(00)00283-2