Hydrazinocurcumin, a novel synthetic curcumin derivative, is a potent inhibitor of endothelial cell proliferation

Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (B...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2002-08, Vol.10 (8), p.2439-2444
Main Authors: JOONG SUP SHIM, DONG HOON KIM, SHIN, Jongheon, HO JEONG KWON, HYE JIN JUNG, JIN HEE KIM, LIM, Dongyeol, LEE, Seok-Ki, KIM, Kyu-Won, JONG WOONG AHN, YOO, Jong-Shin, RHO, Jung-Rae
Format: Article
Language:English
Subjects:
Angiogenesis Inhibitors - chemical synthesis
Angiogenesis Inhibitors - pharmacology
Animals
Antineoplastic agents
Biological and medical sciences
Cattle
Cell Division - drug effects
Chick Embryo
Curcumin - analogs & derivatives
Curcumin - chemical synthesis
Curcumin - pharmacology
Dose-Response Relationship, Drug
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
General aspects
Hydrazines - chemical synthesis
Hydrazines - pharmacology
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Medical sciences
Molecular Structure
Neovascularization, Physiologic - drug effects
Pharmacology. Drug treatments
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Summary:Curcumin and some of its derivatives were known as in vivo inhibitors of angiogenesis. In present study, a novel curcumin derivative, named hydrazinocurcumin (HC) was synthesized and examined for its biological activities. HC potently inhibited the proliferation of bovine aortic endothelial cells (BAECs) at a nanomolar concentration (IC(50)=520 nM) without cytotoxicity. In vivo and in vitro angiogenesis experiments showed HC as a new candidate for anti-angiogenic agent.
ISSN:0968-0896
1464-3391
DOI:10.1016/s0968-0896(02)00116-5