Anti-HIV-1 peptides derived from partial amino acid sequences of CC-Chemokine RANTES

Fifteen acetyl-peptide-amides with partial amino acid sequences of RANTES (regulated upon activation, normal T-cell expressed and secreted), all Cys residues of which were substituted by Ala, were synthesized, and screened for anti-HIV-1 activity. Peptides corresponding to 1–10, 37–46, and 57–68 sho...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2002-12, Vol.10 (12), p.4113-4117
Main Authors: Nishiyama, Yasuhiro, Murakami, Tsutomu, Shikama, Suguru, Kurita, Keisuke, Yamamoto, Naoki
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Fifteen acetyl-peptide-amides with partial amino acid sequences of RANTES (regulated upon activation, normal T-cell expressed and secreted), all Cys residues of which were substituted by Ala, were synthesized, and screened for anti-HIV-1 activity. Peptides corresponding to 1–10, 37–46, and 57–68 showed marked activity against CC-chemokine receptor 5-using HIV-1 JR-CSF (% inhibition at 100 nM 69, 82, 76%, respectively). The results indicate that multiple regions, including the N-terminal part responsible for chemotactic activity, are involved in anti-HIV-1 activity of RANTES, yielding possible lead compounds for anti-HIV-1 agents. Graphic
ISSN:0968-0896
1464-3391
DOI:10.1016/S0968-0896(02)00271-7