Technetium-99m labeling of tityustoxin and venom from the scorpion Tityus serrulatus

The tityustoxin, the most toxic fraction from scorpion Tityus serrulatus venom, has been used as a tool in several neurochemical and neuropharmacological studies. Biological activities of labeled and unlabeled tityustoxin and venom were compared. The samples were labeled in the presence of stannous...

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Bibliographic Details
Published in:Applied radiation and isotopes 2002-12, Vol.57 (6), p.849-852
Main Authors: Nunan, E.A, Cardoso, V.N, Moraes-Santos, T
Format: Article
Language:English
Subjects:
Animals
Labeling
LD 50
Organotechnetium Compounds - chemistry
Scorpion venom
Scorpion Venoms - chemistry
Scorpions
Technetium-99m
Tityustoxin
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Summary:The tityustoxin, the most toxic fraction from scorpion Tityus serrulatus venom, has been used as a tool in several neurochemical and neuropharmacological studies. Biological activities of labeled and unlabeled tityustoxin and venom were compared. The samples were labeled in the presence of stannous chloride and sodium borohydride with a yield of 60–70% for the venom and 75–85% for tityustoxin and then chromatographed in Sephadex G-10. Biological activities of tityustoxin and venom were preserved after labeling.
ISSN:0969-8043
1872-9800
DOI:10.1016/S0969-8043(02)00197-5