Effect of chemotherapy on pulmonary epithelial permeability in lung cancer

• Published in: Nuclear medicine and biology 2000-08, Vol.27 (6), p.581-585
• Main Authors: Sayıt, Elvan, Aktoğu, Serir, Ertay, Türkan, Çapa, Gamze, Erkmen, Gülin, Özbilek, Engin, Büyükşirin, Melih, Durak, Hatice
• Format: Article
• Language: English
• Subjects: 99mTc-DTPA inhalation scintigraphy; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Blood Gas Analysis; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Small Cell - drug therapy; Carcinoma, Small Cell - metabolism; Cell Membrane Permeability - drug effects; Chemotherapy; Cisplatin - administration & dosage; Doxorubicin - administration & dosage; Etoposide - administration & dosage; Forced Expiratory Volume - drug effects; Humans; Ifosfamide - administration & dosage; Lung - drug effects; Lung - metabolism; Lung - pathology; Lung cancer; Lung Neoplasms - drug therapy; Lung Neoplasms - metabolism; Male; Medical sciences; Metabolic Clearance Rate - drug effects; Middle Aged; Mitomycin - administration & dosage; Mucociliary Clearance - drug effects; Pneumology; Respiratory Mucosa - drug effects; Respiratory Mucosa - metabolism; Technetium Tc 99m Pentetate - administration & dosage; Technetium Tc 99m Pentetate - pharmacokinetics; Tumors of the respiratory system and mediastinum; Vital Capacity - drug effects
• ISSN: 0969-8051; 1872-9614
• DOI: 10.1016/S0969-8051(00)00133-5

The aim of this study is to investigate the effect of one-course chemotherapy on the pulmonary epithelial permeability. Eighteen patients (18 male; mean age: 59±10 years) with lung cancer (11 non-small cell, 7 small cell) inhaled 40 mCi (1,480 MBq) 99mTc-diethylenetriaminepentaacetic acid (DTPA). Thirty images of 1-min duration were acquired from posterior projection. The first 7 min of the decay-corrected time activity curves were used to calculate lung clearance half-time. Clearance half-times of 99mTc-DTPA from the peripheral regions of the lungs were 42 ± 19 min before and 56±34 min after chemotherapy ( p =0.009 ); from the central regions, clearance half-times were 112±94 min before and 160±125 min after chemotherapy ( p =0.005 ). This decrease in clearance rate might be related to decreasing mucociliary clearance rate due to the toxic effect of the chemotherapy regimen on cilia movement and/or mucus structure. 99mTc-DTPA radioaerosol study can be used to monitor the toxic effects of chemotherapy on the pulmonary epithelium and possibly on mucociliary function.