Pulse radiolysis studies of etoposide and 4′-demethylepipodophyllotoxin in aqueous solution

The reactions of etoposide (VP 16, 4′-demethyl-epipodophyllotoxin ethylidene- β- d-glucoside) and 4′-demethylepipodophyllotoxin (DMEP) with the primary radiolytic products of water, such as e − aq, H and OH/O − radicals, and the secondary radical (SO − 4) in aqueous solution were studied by use of t...

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Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2000-02, Vol.57 (2), p.151-156
Main Authors: Lu, Chang-yuan, Wang, Wen-feng, Lin, Wei-zhen, Xu, Qiang-guo, Pan, Jing-xi, Han, Zhen-hui, Yao, Si-de, Lin, Nian-yun
Format: Article
Language:English
Subjects:
DMEP
Etoposide (VP 16)
Pulse radiolysis
Redox reactions
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Summary:The reactions of etoposide (VP 16, 4′-demethyl-epipodophyllotoxin ethylidene- β- d-glucoside) and 4′-demethylepipodophyllotoxin (DMEP) with the primary radiolytic products of water, such as e − aq, H and OH/O − radicals, and the secondary radical (SO − 4) in aqueous solution were studied by use of the techniques of pulse radiolysis, respectively. The absorption spectra of reaction products with e − aq, H and OH/O − and SO − 4 radicals were observed, and the rate constants of them were determined by following the build-up kinetics of radicals produced or the decay of hydrated electron observed at 600 nm, respectively.
ISSN:0969-806X
1879-0895
DOI:10.1016/S0969-806X(99)00321-7