In-vitro evaluation of Mg-4.0Zn-0.2Ca alloy for biomedical application

The in-vitro degradation and in-vitro cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy were investigated. The in-vitro corrosion tests indicate that Zn and Ca elements can dramatically increase the corrosion potential of the as-extruded Mg-4.0Zn-0.2Ca alloy in the simulated body fluid and reduce...

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Bibliographic Details
Published in:Transactions of Nonferrous Metals Society of China 2011-08, Vol.21, p.s252-s257
Main Authors: SUN, Yu, KONG, Min-xiu, JIAO, Xiao-hui
Format: Article
Language:English
Subjects:
biocompatibility
biodegradation
cytotoxicity
magnesium alloy
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Summary:The in-vitro degradation and in-vitro cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy were investigated. The in-vitro corrosion tests indicate that Zn and Ca elements can dramatically increase the corrosion potential of the as-extruded Mg-4.0Zn-0.2Ca alloy in the simulated body fluid and reduce the degradation rate. The cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy examined by MTT tests on L929 cells suggest that the alloy has eligible toxicity for implant applications.
ISSN:1003-6326
DOI:10.1016/S1003-6326(11)61587-2