Separation of α-Tocopherol with a Two-Feed Simulated Moving Bed

• Published in: Chinese journal of chemical engineering 2012-08, Vol.20 (4), p.673-678
• Main Author: 危凤 沈波 陈明杰 周先波 赵迎宪
• Format: Article
• Language: English
• Subjects: simulated moving bed; SMB; tocopherol; two-feed; α-生育酚; 中间馏分; 分离; 固定相; 模拟移动床; 运动区域; 进料
• ISSN: 1004-9541; 2210-321X
• DOI: 10.1016/S1004-9541(11)60234-6

A two-feed simulated moving bed（SMB） was proposed to utilize the stationary phase more effectively.Zone I is disconnected with zone Ⅱ and zone Ⅲ is disconnected with zone IV.Two feeds are added to zones I and Ⅲ,while two desorbents are added to zones Ⅱ and IV separately.The investigation on the movement of concentra-tion bands indicated that the tail of the strong retained solute and the front of the weak retained solute were eluted from zones I and Ⅲ orderly,so the streams from zones I and Ⅲ could be cut into different fractions to give the products with high purity.The two-feed SMB was used to separate α-tocopherol from its homologue mixture suc-cessfully,and could double the productivity if both feeds were identical to the feed in the conventional four-zone SMB.The solvent consumption could be reduced by reusing the middle fraction without solutes.