Monophotonic ionization of etoposide in aqueous solution by 248 nm laser light: identification of transient intermediates

Using 248 nm laser flash photolysis, it has been demonstrated that etoposide (VP16, 4′-demethyl-epipodophyllotoxin ethylidene-β-D-glucoside) in aqueous solution is ionized via a monophotonic process giving a hydrated electron and neutral radical that results from rapid deprotonation of the radical c...

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Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 1999-03, Vol.49 (1), p.61-64
Main Authors: Lu, Chang-Yuan, Wang, Wen-Feng, Lin, Wei-Zhen, Han, Zhen-Hui, Pan, Jing-Xi, Yao, Si-De, Lin, Nian-Yun
Format: Article
Language:English
Subjects:
Etoposide (VP16)
Laser flash photolysis
Monophotonic ionization
Radicals
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Summary:Using 248 nm laser flash photolysis, it has been demonstrated that etoposide (VP16, 4′-demethyl-epipodophyllotoxin ethylidene-β-D-glucoside) in aqueous solution is ionized via a monophotonic process giving a hydrated electron and neutral radical that results from rapid deprotonation of the radical cation of etoposide. The quantum yield of photoionization is determined to be 0.17 at room temperature with KI solution used as a reference. On the basis of comparison of the result with that obtained from pulse radiolysis, the reaction mechanism has been unambiguously identified.
ISSN:1011-1344
1873-2682
DOI:10.1016/S1011-1344(99)00017-2