Severe restriction in jaw movement after routine injection of local anesthetic in patients who have fibrodysplasia ossificans progressiva

Objective. To determine the relationship of dental procedures to immediate ossification and ankylosis of the jaw inpatients who have fibrodysplasia ossificans progressiva. Study design. A mail survey was conducted of the 60 patient-members of the International Fibrodysplasia Ossificans Progressiva A...

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Published in:Oral surgery, oral medicine, oral pathology, oral radiology and endodontics oral medicine, oral pathology, oral radiology and endodontics, 1996, Vol.81 (1), p.21-25
Main Authors: Luchetti, Wayne, Cohen, Randolph B., Hahn, Gregory V., Rocke, David M., Helpin, Mark, Zasloff, Michael, Kaplan, Frederick S.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anesthesia
Anesthesia depending on patient's condition
Anesthesia, Dental - adverse effects
Anesthesia, Local - adverse effects
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Local - administration & dosage
Anesthetics, Local - adverse effects
Ankylosis - etiology
Biological and medical sciences
Child
Child, Preschool
Dental Restoration, Permanent
Female
Follow-Up Studies
Humans
Injections, Subcutaneous - adverse effects
Male
Mandible - physiopathology
Masticatory Muscles - physiopathology
Medical sciences
Middle Aged
Myositis Ossificans - complications
Myositis Ossificans - physiopathology
Orthodontic Appliances
Ossification, Heterotopic - etiology
Risk Factors
Temporomandibular Joint Disorders - etiology
Tooth Extraction
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Summary:Objective. To determine the relationship of dental procedures to immediate ossification and ankylosis of the jaw inpatients who have fibrodysplasia ossificans progressiva. Study design. A mail survey was conducted of the 60 patient-members of the International Fibrodysplasia Ossificans Progressiva Association. All 41 patients (18 males, 23 females) who responded were examined. Instantaneous exact hazard rates for ossification of the jaw were calculated by the Weibull model. Results. Thirty-six patients had dental procedures performed. Twenty-one (58%) patients had received an injection of local anesthetic. Five (24%) patients had an immediate flare-up of fibrodysplasia ossificans progressiva with ossification and permanent ankylosis of the jaw (expected occurrence, 0.031; p
ISSN:1079-2104
1528-395X
DOI:10.1016/S1079-2104(96)80141-7