The role of inflammatory mediators in necrotizing enterocolitis

Inflammatory mediators such as macrophage-derived cytokines, tumour necrosis factor and interleukins, platelet-activating factor, oxygen-derived free radicals, leukotrienes and complement play an important role in the pathophysiology of multisystem organ failure (MSOF). The similarity in clinical pr...

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Bibliographic Details
Published in:Seminars in neonatology 1997, Vol.2 (4), p.273-280
Main Authors: Morecroft, James A., Spitz, Lewis
Format: Article
Language:English
Subjects:
interleukin-1
interleukin-6
ischaemia reperfusion injury
platelet-activating factor
tumour necrosis factor
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Summary:Inflammatory mediators such as macrophage-derived cytokines, tumour necrosis factor and interleukins, platelet-activating factor, oxygen-derived free radicals, leukotrienes and complement play an important role in the pathophysiology of multisystem organ failure (MSOF). The similarity in clinical presentation between MSOF and necrotizing enterocolitis (NEC) is considered and the evidence for a possible role of these inflammatory mediators in NEC explored.
ISSN:1084-2756
1532-2815
DOI:10.1016/S1084-2756(97)80034-6