Detection of an antigenic protein of Leptospira interroganswhich shares epitopes with the equine cornea and lens

A protein epitope which is involved in an antigenic relationship between equine ocular tissues and Leptospira interrogans was detected in homogenates of the bacterium. The antigenic determinant was harboured on a peptide structure which was shown to be sensitive to the action of denaturing and reduc...

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Bibliographic Details
Published in:The veterinary journal (1997) 1997, Vol.153 (1), p.75-79
Main Authors: Parma, A.E., Sanz, M.E., Lucchesi, P.M., Mazzonelli, J., Petruccelli, M.A.
Format: Article
Language:English
Subjects:
antigen
cornea
equine
immunogold
Leptospira
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Summary:A protein epitope which is involved in an antigenic relationship between equine ocular tissues and Leptospira interrogans was detected in homogenates of the bacterium. The antigenic determinant was harboured on a peptide structure which was shown to be sensitive to the action of denaturing and reducing agents by means of Western blotting. The outer surface of the leptospires appeared to be free of this epitope as was proved by dot-blot and electron microscopic studies.
ISSN:1090-0233
1532-2971
DOI:10.1016/S1090-0233(97)80011-1