P54 – 2942: Controlled evaluation of serum lipid levels and carotid artery intima media thickness in idiopathic epileptic children treated with valproic acid, carbamazepine and levetiracetam

• Published in: European journal of paediatric neurology 2015-05, Vol.19, p.S109-S109
• Main Authors: Aksoy, B, Doksöz, Ö, Ünalp, A, Meşe, T, Ünal, N, Özdemir, R, Küçük, M, Yilmazer, M.M
• Format: Article
• Language: English
• Subjects: Neurology; Pediatrics
• ISSN: 1090-3798; 1532-2130
• DOI: 10.1016/S1090-3798(15)30367-6

Objective It is aimed to evaluate the tendency for atherosclerosis in idiopathic epileptic children treated with valproic acid, carbamazepine and levetiracetam by measuring the serum cholesterol levels and carotid artery intima media thickness which is thougt to be the indirect marker of subintimal lipid deposition. Methods The study included 54 children with idiopathic epilepsy aged between 6 to 12 years who had been receiving monoterapy with valproic acid (n=24), carbamazepine (n=15) or levetiracetam (n=15) at least for one year. A control group of 20 healthy children with similar characteristics as age and sex were also included for the study. Serum concentrations of triglyceride, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL) were measured in all patients. Patients with hypertension, history of smoking, diabetes mellitus, familial hypercholesterolemia, family history of early atherosclerosis, chronic illness aside from epilepsy, relative weigth >120% (obese) were not included for the study. Results All of the epileptic patients of the study group had generalized epilepsy. No statistically significant difference was detected between the epileptic children of the study and the healthy control group in respect to age and sex distrubution (P