Evolutionary changes in mutation rates and spectra and their influence onthe adaptation of pathogens

The evolutionary tuning of mutational processes may play a key role in prokaryotic evolution, particularly among pathogens. In this paper we review the evidence that genetic systems controlling the rate and spectrum of heritable mutations have evolved to optimize levels of adaptive variation and rat...

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Bibliographic Details
Published in:Microbes and Infection 2000, Vol.2 (12), p.1513-1522
Main Authors: Metzgar, David, Wills, Christopher
Format: Review
Language:English
Subjects:
biological adaptation
drug resistance
evolution
host–parasite relations
mutagenesis
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Summary:The evolutionary tuning of mutational processes may play a key role in prokaryotic evolution, particularly among pathogens. In this paper we review the evidence that genetic systems controlling the rate and spectrum of heritable mutations have evolved to optimize levels of adaptive variation and rates of genetic change.
ISSN:1286-4579
1769-714X
DOI:10.1016/S1286-4579(00)01306-X