Synthetic applications of epoxide hydrolases

There have been several recent advances in the area of biocatalysed hydrolytic kinetic resolution of epoxides using ‘newly discovered’ enzymes (i.e. epoxide hydrolases). These biocatalysts, two of which will become commercially available in the near future, appear to be highly promising tools for fi...

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Bibliographic Details
Published in:Current Opinion in Chemical Biology 2001-04, Vol.5 (2), p.112-119
Main Authors: Archelas, Alain, Furstoss, Roland
Format: Article
Language:English
Subjects:
Aspergillus niger - enzymology
Aspergillus niger - genetics
biocatalysis
Biomass
Biotechnology - trends
Cloning, Molecular
Epoxide hydrolase
Epoxide Hydrolases - chemistry
Epoxide Hydrolases - metabolism
Epoxy Compounds - chemical synthesis
Epoxy Compounds - chemistry
Hydrolysis
Mevalonic Acid - analogs & derivatives
Mevalonic Acid - chemical synthesis
Mevalonic Acid - metabolism
Mutagenesis, Site-Directed - genetics
resolution
Rhizobium - enzymology
Rhizobium - genetics
Stereoisomerism
Substrate Specificity - physiology
synthesis
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Summary:There have been several recent advances in the area of biocatalysed hydrolytic kinetic resolution of epoxides using ‘newly discovered’ enzymes (i.e. epoxide hydrolases). These biocatalysts, two of which will become commercially available in the near future, appear to be highly promising tools for fine organic synthesis, as they enable the preparation of various epoxides and/or their corresponding diols in enantiopure form.
ISSN:1367-5931
1879-0402
DOI:10.1016/S1367-5931(00)00179-4