Retinoids in combination therapies for the treatment of cancer: mechanisms and perspectives

Retinoid derivatives have been of special interest in cancer research because of their antiproliferative and differentiation-inducing activities in premalignant and malignant cells. Some retinoids are clinically effective in cancer therapy and prevention, and all- trans-retinoic acid is being used f...

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Bibliographic Details
Published in:Drug resistance updates 2002-07, Vol.5 (3), p.162-175
Main Authors: Ortiz, Maria A, Bayon, Yolanda, Lopez-Hernandez, Francisco J, Piedrafita, F.Javier
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Apoptosis
Apoptosis - drug effects
Clinical Trials as Topic
Combination therapy
Humans
Neoplasms - drug therapy
Retinoid-related molecules
Retinoids
Retinoids - therapeutic use
Stereoisomerism
Structure-Activity Relationship
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Summary:Retinoid derivatives have been of special interest in cancer research because of their antiproliferative and differentiation-inducing activities in premalignant and malignant cells. Some retinoids are clinically effective in cancer therapy and prevention, and all- trans-retinoic acid is being used for the treatment of acute promyelocytic leukemia. Unfortunately, classical retinoids are not effective against most advanced solid tumors and cause undesirable side effects, which have limited the full development of retinoids as chemopreventive and chemotherapeutic drugs. The recent identification of selective retinoid derivatives capable of inducing apoptosis and their combination with other anticancer therapies promises a more effective and less toxic manner to the successful use of retinoids in cancer therapy.
ISSN:1368-7646
1532-2084
DOI:10.1016/S1368-7646(02)00050-X